我们如何提供新的希望患有帕金森症?

“For neurology, it was such a fascinating topic. Everything we feel and what we process comes from the brain,” Facheris says. “It’s not really your gut. It’s the brain and a bunch of neurotransmitters that create a thought, a feeling, or a movement. I just fell in love.” 

For the first time, Facheris says, he was in the front row. Later, during his medical residency in Milan, Italy, he took interest in neurodegenerative disease research, Parkinson’s specifically. Parkinson’s disease is a neurodegenerative disorder where neurons in the brain lose their ability to produce dopamine, which leads to muscular rigidity, tremors and slowness of movement. 

More than 10 million people worldwide are living with Parkinson’s disease, according to the Parkinson’s Foundation, with new diagnoses expected to rise along with an aging population. The need for continued research and effective treatments served as motivation for Facheris, who watched both his uncle and his close friend, only 36 years old, struggle with the disease. 

“I thought if we could stop those neurons from dying and make them regrow, we could restore their function and, for example, help patients regain control of their movement,” Facheris says. “That’s compared to Alzheimer’s, where the main work is focused on preventing further degeneration. Once the neurons that created a memory are gone, that memory is gone forever, as well as the personality of that patient, even if we could put in new neurons.” 

起初,他可能没有被热切的学生在医学院第一行,但Maurizio Facheris,医学博士早知道他对科学很感兴趣,高中以来的遗传学和生物学。出生于意大利的医生认为药让他把这些利益和帮助别人。起初,他认为他的职业是心脏外科医生,但学习心脏没有唤起激情时,他觉得坐在不同的讲座。 讲座是关于大脑

“神经学,它是这样一个有趣的话题。一切我们觉得我们过程来自大脑,”Facheris说。“这不是你的肠道。大脑和一群神经递质,创建一个想法,一种感觉,或运动。我只是爱上了。” 

Facheris说,第一次,他在第一排。之后,医疗期间居住在米兰,意大利,他的兴趣在神经退行性疾病的研究中,帕金森症。帕金森病是一种神经退行性疾病,大脑中的神经元失去能力产生多巴胺,导致肌肉僵硬、震动和移动缓慢, 

全世界超过1000万人患有帕金森症,根据帕金森基金会与新诊断,随着人口老龄化将上升。需要继续研究和有效的治疗方法作为动机Facheris,看他的叔叔和他的亲密的朋友,只有36岁,与疾病斗争。 

“我认为如果我们能阻止这些神经元死亡,使其再生,我们可以恢复其功能,例如,帮助患者重新控制运动,“Facheris说。相比,“这是阿尔茨海默氏症,主要工作重点是防止进一步退化。一旦神经元,创建了一个记忆,记忆是一去不复返,以及病人的人格,即使我们可以把新的神经元。” 

During this time, Facheris was busy with medical research and treating patients as a research fellow at the Mayo Clinic in Rochester, Minnesota, and then back home in Italy at a local hospital, where he joined a consortium supported by a Michael J. Fox Foundation (MJFF) grant. This involvement led to a job opportunity with the Foundation itself, where Facheris leveraged his experience as a physician and researcher.

“Through the Foundation, I met many patients and heard how the disease was impacting their daily life,” he says. “People with Parkinson’s wanted to sleep better, move better. Their hopes were for a cure so they could have their lives back.”

One such patient is Barry, who lives in Nebraska in the United States and was diagnosed with Parkinson’s in 2012. Although his disease is well-managed through medication, he says that no one understands better the urgency associated with advancing research and treatment than patients. “We all want the solution now.”

到2000年代初,帕金森承认和理解由于几个高调的病人。的演员迈克尔·j·福克斯在1998年宣布他的诊断和两年之后,他开始与一个基金会,紧急任务:消除帕金森病。

在这段时间里,Facheris忙于医学研究和治疗病人作为一个研究员罗彻斯特市梅奥诊所的明尼苏达州,然后回家在意大利当地医院,在那里他加入一个财团支持迈克尔·j·福克斯基金会(MJFF)资助。这个基金会的介入导致了工作机会本身,在Facheris杠杆他作为一名医生和研究人员的经历。

“通过基金会,我遇到了许多病人,听到疾病是如何影响他们的日常生活,”他说。“帕金森患者想睡得更好,更好。他们的希望是治愈,这样他们可以有自己的生活。”

巴里就是这样一个病人,他生活在美国内布拉斯加州,2012年被诊断出患有帕金森症。虽然他的病是通过药物管理良好,他说,没有人理解与促进研究和治疗相关的紧迫性比病人。“现在我们都希望解决方案。”

“Progress toward a Parkinson’s cure requires many talented, passionate people working together,” added Todd Sherer, Ph.D., MJFF’s executive vice president of research strategy. “We at the Foundation are grateful to Maurizio for the contributions he is making toward our shared goal of a world without this disease and glad that we can still work with him closely.”

More than 20 years after falling in love with neurological research, Facheris is hopeful for the thousands of patients he’s connected with during his career. He says scientists have a better understanding of what’s happening within the proteins of the brain and how they could target them to help slow down the progression of the disease.

“When I came to AbbVie, I thought of my friend and of those 1,500 Parkinson’s patients I would see as a physician in Italy. I think of the patients I met while in the nonprofit sector, and I know here I can reach hundreds of thousands of people,” says Facheris. “Where we are today, I can say in my lifetime we will find an answer to modify Parkinson’s disease and slow progression and for that I’m excited and hopeful.”

总是知道帕金森患者想要治愈,Facheris在神经科学发展作为医疗主任AbbVie。狗万正网地址“我喜欢,在AbbVie,我们看到病人从一开始的晚期疾病。”

“进展帕金森治疗需要许多有才华的,充满激情的人一起工作,”托德•谢尔补充说博士MJFF研究战略的执行副总裁。“我们在基金会感谢Maurizio贡献他正在朝着我们共同的目标是一个没有这种疾病的世界和高兴,我们仍然可以与他合作密切。”

20多年后会爱上神经学研究,Facheris对数以千计的病人希望他与在他的职业生涯。他说科学家们更好地了解大脑的蛋白质内发生了什么和如何目标他们帮助减缓疾病的进展。

“当我来到AbbVie,我想起了我的朋友,1500年的帕金森患者我将作为一名医生在意大利。我认为的病人我遇到在非营利部门,我知道我可以达到数十万人,“Facheris说。”,今天,我可以说在我有生之年我们会找到答案修改帕金森病和缓慢进展,为此,我感到很兴奋和希望。”

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