追逐的价值走在地毯上

For example, what dollar amount would you put on a few more months of life that will allow you to walk your daughter down the aisle?

Whether we’re thinking about life’s major milestones or mundane daily activities, health economics and outcomes research (HEOR) needs to carefully consider the value of these moments.

Despite being data-driven scientists and therefore unlikely to admit it, it could be argued that HEOR professionals use shades of philosophy and sociology to add context to their calculations.

Even with a seemingly clear-cut tool like the utility approach, a measurement to assess quality of life often used in clinical trials, understanding the human face of the data is vital.

Patients are asked to rate their tolerance of treatment adverse events, using a scale of zero to one. However, measuring utilities may be tricky as different patients may produce different results.

“If I’m an Olympic athlete and my life revolves around running, I may rate severe knee pain as a 0.3, meaning highly debilitating. But, let’s say the person is a violinist and can sit in a chair while they do and what they love. For them, it is still a terrible burden, but they may score it as less debilitating. Different people have different values,” says Anthony Wang, U.S. immunology – gastroenterology lead, HEOR, AbbVie.

价值评估通常是通过数学方程,但对于大多数人来说很难看到数学的客观绝对可以充分告知emotion-driven决定生死。

例如,你会穿上什么金额的生活几个月,会让你与你的女儿一起走走道?

我们是否思考人生的重大里程碑或平凡的日常活动,卫生经济学研究和成果(HEOR)需要仔细考虑这些时刻的价值。

尽管数据驱动的科学家,因此不太可能承认,它可能是认为HEOR专业人士使用的哲学和社会学添加上下文计算。

即使像一个看似明确的工具实用的方法,测量评估生活质量在临床试验中经常使用,理解的人脸数据是至关重要的。

患者要求治疗的不良事件的公差,使用一个0到1的规模。然而,测量工具可能是很复杂的,不同的病人可能产生不同的结果。

“如果我是一个奥林匹克运动员,我的生活围绕着跑步,我可能率严重的膝盖疼痛为0.3,意义非常衰弱。但是,假设人是一个小提琴家,坐在椅子上时能做他们的爱。对他们来说,这仍然是一个可怕的负担,但是他们可能得分少衰弱。不同的人有不同的价值观,”安东尼说,美国免疫学-胃肠病学领先,HEOR, AbbVie。

Measuring the patient experience involves pairing patient reported outcomes (PROs) – data coming directly from the patient about their health – with clinical data.

For example, a patient whose clinical data show a three-point, statistically significant reduction in swelling may be considered a positive outcome.

“However, if those three points are dropping a patient from bad to still bad as measured by their PRO, it may not be as meaningful to the patient despite being statistically significant,” Pinsky says.

主要药物一直是判断在安全性和有效性。然而,随着测量病人的经验已成为越来越重要的拼图的价值,HEOR领域已成为积分。

测量病人的经验包括配对病人报告结果(优点)——数据直接从病人对他们的健康——临床资料。

例如,一个病人的临床数据显示一个三分,显著减少肿胀可能被视为一个积极的结果。

“然而,如果这三个点是把病人从坏还坏来衡量他们的职业,它可能不是有意义的病人尽管是统计学意义,“平斯基说。

“We work with both clinical trial data and real world evidence to determine the value of medicines,” Wang says. “This requires gaining insight about key issues from patients, physicians, as well as payers.”

Take Pinsky’s experience with his grandfather’s broken hip.

Had he had done an economic analysis, Pinsky would have had a difficult time showing a payer that hip surgery would be cost effective. But there were clearly more factors to consider in defining the value of an intervention than cost-effectiveness alone – and recognizing these factors are what HEOR does best.

\n“Ultimately, our goal is to show how patients’ lives are changed for the better,” Wang says. “At the end of the day, understanding the value of a medicine is about the patients’ journey, their story.”

HEOR看起来不错的整体,研究大型患者群体评估价值。

“我们与临床试验数据和工作现实世界的证据来确定药物的价值”,王说。“这需要获得病人了解关键问题,医生,以及纳税人。”

品的祖父的髋骨骨折的经验。

他做了一个经济分析、品会有很难显示付款人,臀部手术将成本效益。但是显然有更多因素需要考虑单独定义的价值干预的成本效益,并认识到这些因素是什么HEOR最好。

“最终,我们的目标是显示病人的生活变好,”王说。“在一天结束的时候,理解医学的价值是关于病人的旅程,他们的故事。”